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Taurine for dogs trial#

Taurine for dogs trial#

Kittleson M D et al (1997) Results of the Multicenter Spaniel Trial (MUST): Taurine-and Carnitine-Responsive Dilated Cardiomyopathy in American Cocker Spaniels with Decreased Plasma Taurine Concentration.Vet Clin North Am Small Anim Pract 36(6), 1325-1343 PubMed. Sanderson S L (2006) Taurine and carnitine in canine cardiomyopathy.Recent references from PubMed and VetMedResource.DCM Heart: dilated cardiomyopathy (DCM) Heart: occult dilated cardiomyopathy.įurther Reading Publications Refereed Papers.Deficiency → disruption of cell membranes → cell degeneration and death →.Acts as a natural antagonist of angiotensin II.Directly affects contractile proteins in the heart.

Regulates flux of potassium and calcium ions across photoreceptor and myocardial cell membranes.

Exact role of taurine in tissue metabolism unclear:.

Predisposed breeds may have altered taurine metabolism or requirements.

Dogs can endogenously synthesize adequate amounts of taurine from cystine and methionine.

Low plasma taurine has been demonstrated in some dogs with this disease and some have developed DCM that responded to taurine and carnitine L-carnitine supplementation.

Cystinuria Urolithiasis: failure of absorption of cysteine from the urine.

Investigations are ongoing as to the underlying cause of DCM in these cases, but it is currently unknown if it is related to taurine deficiency. These diets generally had methionine and cysteine values above the minimum requirements. DCM has more recently been reported in dogs receiving grain-free diets and diets high in peas, lentils and potatoes.

Diet: vegetarian, restricted protein, high-fiber, lamb and rice.

A relationship between DCM and taurine Taurine has not been found in English Cocker Spaniels but measurement of taurine levels and supplementation is still currently recommended if DCM is identified.

Breed: predisposed breeds include American Cocker Spaniels, Golden Retrievers, Portuguese Water Dogs and some Newfoundlands.